denbi-modsim.github.io

de.NBI workshop: Constraint-based modeling and design of metabolic networks with CellNetAnalyzer and CNApy

Educators:

Steffen Klamt, Axel von Kamp, Pavlos Bekiaris

(Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany)

Date:

Day 1: 5-Nov-2024 2:00 pm - 6:00 pm (CET / UTC +1)

Day 2: 6-Nov-2024 2:00 pm - 6:00 pm (CET / UTC +1)

Location:

Online Conferencing (Link will be provided to Registered and confirmed participants)

Abstract

This 2-days course introduces principles of constraint-based modeling and computational design of metabolic networks coupled with a live demonstration and hands-on exercises with the MATLAB package CellNetAnalyzer (CNA) and its Python-variant CNApy.

Day 1

Overview of key methods of constraint-based modeling and metabolic network design (coupled with live demonstration of CNA and CNApy):

• Fundamentals of constraint-based modeling of metabolic networks
• Metabolic flux (balance) analysis
• Flux Variability analysis
• Phase planes and Yield spaces
• Metabolic pathway analysis
• Minimal cut sets and computational design of metabolic networks

Day 2

Hands-on exercises with CNA and CNApy: the participants will practice the use of CNA or/and CNApy by exercises with small example networks as well as with realistic metabolic models.

Registration

Registration

This workshop is part of the de.NBI SysBio Workshop series 2024. more information